Arhgef2^tm1Sixt
Targeted Allele Detail

Summary

• Symbol: Arhgef2^tm1Sixt
• Name: Rho/Rac guanine nucleotide exchange factor 2; targeted mutation 1, Michael Sixt
• MGI ID: MGI:7398511
• Synonyms: Lfc^-
• Gene: Arhgef2 Location: Chr3:88513273-88555359 bp, + strand Genetic Position: Chr3, 38.9 cM, cytoband F1
• Alliance: Arhgef2^tm1Sixt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:291291
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The genomic DNA region between base pairs 1193 and 1477, coding for amino acids 351445 in the Dbl homology (DH) domain, and the DH/Pleckstrin homology domain interface were exchanged for a neomycin cassette flanked by LoxP sites. (J:291291)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arhgef2 Mutation: 78 strains or lines available

References

• Original: J:291291 Kopf A, et al., Microtubules control cellular shape and coherence in amoeboid migrating cells. J Cell Biol. 2020 Jun 1;219(6)
• All: 1 reference(s)