Rab6b^em1Baf
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rab6b^em1Baf
• Name: RAB6B, member RAS oncogene family; endonuclease-mediated mutation 1, Alexandre D Baffet
• MGI ID: MGI:7398465
• Gene: Rab6b Location: Chr9:102988986-103062475 bp, + strand Genetic Position: Chr9, 54.88 cM
• Alliance: Rab6b^em1Baf page

Mutation origin

• Strain of Origin: (C57BL/6J x DBA/2J)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Deletion, Inversion
• Mutation details: CRISPR-cas9 mediated recombination using guide RNAs created a 1 bp deletion in exon 2 and a 279 bp inversion resulting in a premature stop codon. (J:330973)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rab6b Mutation: 20 strains or lines available

References

• Original: J:330973 Brault JB, et al., RAB6 and dynein drive post-Golgi apical transport to prevent neuronal progenitor delamination. EMBO Rep. 2022 Oct 6;23(10):e54605
• All: 1 reference(s)