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Prknem1Mjj
Endonuclease-mediated Allele Detail
Summary
Symbol: Prknem1Mjj
Name: parkin RBR E3 ubiquitin protein ligase; endonuclease-mediated mutation 1, Michael J Jurczak
MGI ID: MGI:7398300
Synonyms: Prknfl
Gene: Prkn  Location: Chr17:11059271-12282248 bp, + strand  Genetic Position: Chr17, 7.8 cM, cytoband A3.2-A3.3
Alliance: Prknem1Mjj page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Conditional ready)
Mutation:    Insertion
 
Mutation detailsCRISPR/Cas9 technology inserted loxP sites flanking exon 7, which encodes the RING1 domain and is essential for PARKIN E3 ligase activity. (J:331734)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prkn Mutation:  54 strains or lines available
References
Original:  J:331734 Edmunds LR, et al., Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance. Mol Metab. 2020 Nov;41:101051
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory