Prkn^em1Mjj
Endonuclease-mediated Allele Detail

Summary

• Symbol: Prkn^em1Mjj
• Name: parkin RBR E3 ubiquitin protein ligase; endonuclease-mediated mutation 1, Michael J Jurczak
• MGI ID: MGI:7398300
• Synonyms: Prkn^fl
• Gene: Prkn Location: Chr17:11059271-12282248 bp, + strand Genetic Position: Chr17, 7.8 cM, cytoband A3.2-A3.3
• Alliance: Prkn^em1Mjj page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 technology inserted loxP sites flanking exon 7, which encodes the RING1 domain and is essential for PARKIN E3 ligase activity. (J:331734)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prkn Mutation: 54 strains or lines available

References

• Original: J:331734 Edmunds LR, et al., Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance. Mol Metab. 2020 Nov;41:101051
• All: 2 reference(s)