Kcnh6^em3Jkya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kcnh6^em3Jkya
• Name: potassium voltage-gated channel, subfamily H (eag-related), member 6; endonuclease-mediated mutation 3, Jin-Kui Yang
• MGI ID: MGI:7398298
• Gene: Kcnh6 Location: Chr11:105898950-105925375 bp, + strand Genetic Position: Chr11, 68.87 cM
• Alliance: Kcnh6^em3Jkya page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: CRISPR-cas9 mediated recombination using guide RNAs inserted a construct containing loxP sites around exons 3 and 4. (J:322412)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnh6 Mutation: 49 strains or lines available

References

• Original: J:322412 Zhao MM, et al., Berberine is an insulin secretagogue targeting the KCNH6 potassium channel. Nat Commun. 2021 Sep 23;12(1):5616
• All: 3 reference(s)