Pdk2^tm1.1Cya
Targeted Allele Detail

Summary

• Symbol: Pdk2^tm1.1Cya
• Name: pyruvate dehydrogenase kinase, isoenzyme 2; targeted mutation 1.1, Cyagen Biosciences
• MGI ID: MGI:7398111
• Synonyms: Pdk2^lox
• Gene: Pdk2 Location: Chr11:94917084-94932180 bp, - strand Genetic Position: Chr11, 59.01 cM
• Alliance: Pdk2^tm1.1Cya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:331530
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was floxed and an FRT flanked neo cassette was inserted via homologous recombination. Flp mediated recombination removed the neo cassette. (J:331530)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdk2 Mutation: 22 strains or lines available

References

• Original: J:331530 Kang HJ, et al., Pyruvate dehydrogenase kinase 1 and 2 deficiency reduces high-fat diet-induced hypertrophic obesity and inhibits the differentiation of preadipocytes into mature adipocytes. Exp Mol Med. 2021 Sep;53(9):1390-1401
• All: 1 reference(s)