Kmo^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kmo^em1Cya
• Name: kynurenine 3-monooxygenase; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:7398108
• Gene: Kmo Location: Chr1:175459759-175488419 bp, + strand Genetic Position: Chr1, 81.6 cM
• Alliance: Kmo^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-cas9 mediated recombination removed a genomic region including exon 2 - 6. (J:331535)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kmo Mutation: 39 strains or lines available

References

• Original: J:331535 Zhao J, et al., Kynurenine-3-monooxygenase (KMO) broadly inhibits viral infections via triggering NMDAR/Ca2+ influx and CaMKII/ IRF3-mediated IFN-beta production. PLoS Pathog. 2022 Mar;18(3):e1010366
• All: 1 reference(s)