Gphn^em1Tyas
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gphn^em1Tyas
• Name: gephyrin; endonuclease-mediated mutation 1, Shiva K Tyagarajan
• MGI ID: MGI:7398107
• Synonyms: GphnS268A/S270A
• Gene: Gphn Location: Chr12:78273153-78731546 bp, + strand Genetic Position: Chr12, 35.51 cM, cytoband D2
• Alliance: Gphn^em1Tyas page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• CRISPR-cas9 mediated recombination introduced two mutations, S268A and S270A. (J:331536)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gphn Mutation: 89 strains or lines available

References

• Original: J:331536 Cramer T, et al., Cross-talk between GABAergic postsynapse and microglia regulate synapse loss after brain ischemia. Sci Adv. 2022 Mar 4;8(9):eabj0112
• All: 2 reference(s)