Slc6a2^em1(cre)Lbrl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Slc6a2^em1(cre)Lbrl
• Name: solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2; endonuclease-mediated mutation 1, Stephen Liberles
• MGI ID: MGI:7397278
• Synonyms: Slc6a2-p2a-Cre
• Gene: Slc6a2 Location: Chr8:93687100-93728295 bp, + strand Genetic Position: Chr8, 44.99 cM
• Alliance: Slc6a2^em1(cre)Lbrl page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Slc6a2^em1(cre)Lbrl expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Slc6a2 (MGI:1270850)

• Mutation details: Using the CRISPR/Cas9 technology, a p2a-cre cassette was inserted into the 3' UTR of the mouse Slc6a2 locus. (J:307177)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Slc6a2 (mouse) Summary of all recombinase alleles driven by Slc6a2. Alliance mouse Slc6a2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc6a2 Mutation: 34 strains or lines available

References

• Original: J:307177 Zhang C, et al., Area Postrema Cell Types that Mediate Nausea-Associated Behaviors. Neuron. 2021 Feb 3;109(3):461-472.e5
• All: 1 reference(s)