Trpm4^em1Sthg
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trpm4^em1Sthg
• Name: transient receptor potential cation channel, subfamily M, member 4; endonuclease-mediated mutation 1, Samuel T Hwang
• MGI ID: MGI:7388564
• Synonyms: TRPM4^I1029M
• Gene: Trpm4 Location: Chr7:44952579-44983495 bp, - strand Genetic Position: Chr7, 29.24 cM
• Alliance: Trpm4^em1Sthg page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced the mutation resulting in the amino acid substitution of isoleucine with methionine at position 1029 (I1029M). (J:330963)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trpm4 Mutation: 57 strains or lines available

References

• Original: J:330963 Yamada D, et al., Gain-of-function of TRPM4 predisposes mice to psoriasiform dermatitis. Front Immunol. 2022;13:1025499
• All: 1 reference(s)