Nox4^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nox4^em1Cya
• Name: NADPH oxidase 4; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:7388469
• Gene: Nox4 Location: Chr7:86895304-87047918 bp, + strand Genetic Position: Chr7, 48.96 cM
• Alliance: Nox4^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Not Specified
• CRISPR-targeting generated a null allele. (J:331175)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nox4 Mutation: 73 strains or lines available

References

• Original: J:331175 Han C, et al., NOX4 promotes mucosal barrier injury in inflammatory bowel disease by mediating macrophages M1 polarization through ROS. Int Immunopharmacol. 2022 Mar;104:108361
• All: 1 reference(s)