Senp2^tm2.2Whsu
Targeted Allele Detail

Summary

• Symbol: Senp2^tm2.2Whsu
• Name: SUMO/sentrin specific peptidase 2; targeted mutation 2.2, Wei Hsu
• MGI ID: MGI:7387080
• Gene: Senp2 Location: Chr16:21828234-21868019 bp, + strand Genetic Position: Chr16, 12.98 cM, cytoband B1
• Alliance: Senp2^tm2.2Whsu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228859
• Parent Cell Line: CSL3 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct floxed exon 16. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 16 containing the protease core domain. (J:228859)

Expression

In Mice Carrying this Mutation:

8 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Senp2 Mutation: 51 strains or lines available

References

• Original: J:228859 Fu J, et al., Disruption of SUMO-specific protease 2 induces mitochondria mediated neurodegeneration. PLoS Genet. 2014 Oct;10(10):e1004579
• All: 1 reference(s)