Tg(Vav1-Mpl)EAmol
Transgene Detail

Summary

• Symbol: Tg(Vav1-Mpl)EAmol
• Name: transgene insertion E, Alison Moliterno
• MGI ID: MGI:7387062
• Synonyms: MPLSV(E)
• Transgene: Tg(Vav1-Mpl)EAmol Location: unknown
• Alliance: Tg(Vav1-Mpl)EAmol page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Vav1-Mpl)EAmol expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mpl (MGI:97076)	splice variant

• Mutation details: The transgene is generated using full length Mpl splice variant (SV) cDNA cloned into the HS321/45-vav vector, which contains the mouse genomic Vav1 promoter sequence. The Mpl splice variant has 7 amino acids deleted from the N-terminal domain. Founder line E carries an estimated single copy of the transgene and that the copy number is stable across multiple generations; however the transgene insertion site has not been confirmed. (J:331302)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:331302 Spivak JL, Williams DM, Zhao ZJ, Rogers O, Duffield AS, Hankins WD, Moliterno AR, MPL SV, a Unique MPN MPL Splice Variant, Provokes a Fulminant Myeloid Leukemia in a JAK2 V617F Transgenic Mouse Model of Polycythemia Vera. Blood. 2015;126(23):484
• All: 1 reference(s)