Bhlhe40^em1Mbu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Bhlhe40^em1Mbu
• Name: basic helix-loop-helix family, member e40; endonuclease-mediated mutation 1, Meinrad Busslinger
• MGI ID: MGI:7387032
• Synonyms: Bhlhe40^fl
• Gene: Bhlhe40 Location: Chr6:108637590-108643886 bp, + strand Genetic Position: Chr6, 49.85 cM, cytoband E-F1
• Alliance: Bhlhe40^em1Mbu page

Mutation origin

• Strain of Origin: C57BL/6 x CBA

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• CRISPR-targeting floxed exons 3 and 4. (J:326539)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bhlhe40 Mutation: 53 strains or lines available

References

• Original: J:326539 Rauschmeier R, et al., Bhlhe40 function in activated B and TFH cells restrains the GC reaction and prevents lymphomagenesis. J Exp Med. 2022 Feb 7;219(2):e20211406
• All: 1 reference(s)