Zfp541^em1Qsh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Zfp541^em1Qsh
• Name: zinc finger protein 541; endonuclease-mediated mutation 1, Qinghua Shi
• MGI ID: MGI:7386911
• Gene: Zfp541 Location: Chr7:15795739-15830259 bp, + strand Genetic Position: Chr7, 8.74 cM
• Alliance: Zfp541^em1Qsh page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 1,789 bp deletion in exon 3. Western blot analysis confirmed absence of protein in testicular extracts. (J:324909)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp541 Mutation: 49 strains or lines available

References

• Original: J:324909 Xu J, et al., ZFP541 maintains the repression of pre-pachytene transcriptional programs and promotes male meiosis progression. Cell Rep. 2022 Mar 22;38(12):110540
• All: 1 reference(s)