Kcnb1^em2Sesf
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kcnb1^em2Sesf
• Name: potassium voltage gated channel, Shab-related subfamily, member 1; endonuclease-mediated mutation 2, Frederico Sesti
• MGI ID: MGI:7385068
• Gene: Kcnb1 Location: Chr2:166937889-167032075 bp, - strand Genetic Position: Chr2, 87.22 cM
• Alliance: Kcnb1^em2Sesf page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 genome editing is used to generate a frameshift allele that results in expression of a 337 amino acids truncated protein. This allele is an indel that occurred during the creation of the Kcnb1^em1Sesf allele. (J:331047)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kcnb1 Mutation: 45 strains or lines available

References

• Original: J:331047 Bortolami A, et al., Integrin-KCNB1 potassium channel complexes regulate neocortical neuronal development and are implicated in epilepsy. Cell Death Differ. 2022 Oct 7
• All: 3 reference(s)