Ncapd2^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ncapd2^em1Cya
• Name: non-SMC condensin I complex, subunit D2; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:7384854
• Gene: Ncapd2 Location: Chr6:125144970-125168664 bp, - strand Genetic Position: Chr6, 59.32 cM, cytoband F2
• Alliance: Ncapd2^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology deleted exons 3 to 13. (J:310248)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ncapd2 Mutation: 63 strains or lines available

References

• Original: J:310248 Jing Z, et al., NCAPD2 inhibits autophagy by regulating Ca(2+)/CAMKK2/AMPK/mTORC1 pathway and PARP-1/SIRT1 axis to promote colorectal cancer. Cancer Lett. 2021 Nov 1;520:26-37
• All: 1 reference(s)