Smad4^tm1.1Azun
Targeted Allele Detail

Summary

• Symbol: Smad4^tm1.1Azun
• Name: SMAD family member 4; targeted mutation 1.1, Aimee Zuniga
• MGI ID: MGI:7384563
• Synonyms: Smad4^3xF
• Gene: Smad4 Location: Chr18:73772080-73836851 bp, - strand Genetic Position: Chr18, 49.51 cM
• Alliance: Smad4^tm1.1Azun page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:316178
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Epitope tag)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a triple FLAG tag at the stop codon in exon 12. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted into intron 12. (J:316178)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad4 Mutation: 46 strains or lines available

References

• Original: J:316178 Gamart J, et al., SMAD4 target genes are part of a transcriptional network that integrates the response to BMP and SHH signaling during early limb bud patterning. Development. 2021 Dec 1;148(23):dev200182
• All: 1 reference(s)