Ror1^tm1.1Takt
Targeted Allele Detail

Summary

• Symbol: Ror1^tm1.1Takt
• Name: receptor tyrosine kinase-like orphan receptor 1; targeted mutation 1.1, Takashi Takahashi
• MGI ID: MGI:7382951
• Synonyms: Ror1^f
• Gene: Ror1 Location: Chr4:99952988-100301962 bp, + strand Genetic Position: Chr4, 45.71 cM, cytoband C6
• Alliance: Ror1^tm1.1Takt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:305973
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a loxP site upstream of exon 3 and an FRT-flanked neomycin resistance cassette with a 3 prime loxP site downstream of exon 4. Flp-mediated recombination removed the selection cassette and left exons 3 and 4 floxed. (J:305973)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ror1 Mutation: 58 strains or lines available

References

• Original: J:305973 Isomura H, et al., Conditional Ror1 knockout reveals crucial involvement in lung adenocarcinoma development and identifies novel HIF-1alpha regulator. Cancer Sci. 2021 Apr;112(4):1614-1623
• All: 1 reference(s)