Smpd3^{tm1c(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Smpd3^{tm1c(EUCOMM)Hmgu}
• Name: sphingomyelin phosphodiesterase 3, neutral; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:7382748
• Synonyms: Smpd3^fl
• Gene: Smpd3 Location: Chr8:106979180-107064597 bp, - strand Genetic Position: Chr8, 53.12 cM, cytoband D2
• Alliance: Smpd3^{tm1c(EUCOMM)Hmgu} page
• IMPC: Smpd3 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:330619
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smpd3 Mutation: 46 strains or lines available

References

• Original: J:330619 Schumacher F, et al., Stress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasma. J Mol Med (Berl). 2022 Oct;100(10):1493-1508
• All: 3 reference(s)