Tg(Prnp-CHCHD10*S59L)U1Dkan
Transgene Detail

Summary

• Symbol: Tg(Prnp-CHCHD10*S59L)U1Dkan
• Name: transgenic insertion U1, David Kang
• MGI ID: MGI:7380626
• Synonyms: CHCHD10-S59L
• Transgene: Tg(Prnp-CHCHD10*S59L)U1Dkan Location: unknown Genetic Position: ChrUN, Syntenic
• Alliance: Tg(Prnp-CHCHD10*S59L)U1Dkan page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Epitope tag, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-CHCHD10*S59L)U1Dkan expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CHCHD10 (400916)

  Chchd10

  (MGI:2143558)

  contains S59L mutation

• Mutation details: The transgenic construct contains a FLAG-tagged CHCHD10 S59L mutant cDNA cloned into the expression vector MoPrP.Xho, which contains the mouse genomic prion promoter (Prnp) sequence. (J:306293)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:306293 Liu T, et al., CHCHD10-regulated OPA1-mitofilin complex mediates TDP-43-induced mitochondrial phenotypes associated with frontotemporal dementia. FASEB J. 2020 Jun;34(6):8493-8509
• All: 3 reference(s)