Rgs12^{tm1.1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Rgs12^{tm1.1(KOMP)Vlcg}
• Name: regulator of G-protein signaling 12; targeted mutation 1.1, Velocigene
• MGI ID: MGI:7380593
• Gene: Rgs12 Location: Chr5:35106789-35196988 bp, + strand Genetic Position: Chr5, 17.96 cM
• Alliance: Rgs12^{tm1.1(KOMP)Vlcg} page
• IMPC: Rgs12 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:330604
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre-mediated excision of the parental Rgs12^{tm1.1(KOMP)Vlcg} allele resulted in the removal of the neomycin selection cassette and critical exon(s) leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:330604)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rgs12 Mutation: 61 strains or lines available

References

• Original: J:330604 Akturk A, et al., RGS12 polarizes the GPSM2-GNAI complex to organize and elongate stereocilia in sensory hair cells. Sci Adv. 2022 Oct 21;8(42):eabq2826
• All: 1 reference(s)