Serpine3^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Serpine3^em1(IMPC)J
• Name: serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:7378851
• Gene: Serpine3 Location: Chr14:62901116-62929692 bp, + strand Genetic Position: Chr14, 33.23 cM
• Alliance: Serpine3^em1(IMPC)J page
• IMPC: Serpine3 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences CTGGATGGCTCCCTAAGACA and TAGAATAGACTCAAACTCCA, which resulted in a 593 bp deletion beginning at Chromosome 14 position 62,674,033 bp and ending after 62,674,625 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000883429 (exon 5) and 394 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 231 and early truncation 8 amino acids later. (J:188991)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Serpine3 Mutation: 20 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 2 reference(s)