Apela^em1Hadj
Endonuclease-mediated Allele Detail

Summary

• Symbol: Apela^em1Hadj
• Name: apelin receptor early endogenous ligand; endonuclease-mediated mutation 1, Anna-Katerina Hadjantonakis
• MGI ID: MGI:7378817
• Gene: Apela Location: Chr8:65481069-65489970 bp, - strand Genetic Position: Chr8, 32.52 cM
• Alliance: Apela^em1Hadj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243623
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Plasmids encoding a signal guide RNA are designed to knock-in a H2B-GFP-pA reporter cassette and a loxP site flanked PGK-NEO cassette into exon 2, the endogenous translational start site of the gene. (J:243623)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apela Mutation: 18 strains or lines available

References

• Original: J:243623 Freyer L, et al., Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic Lethality and Defects in Early Mesodermal Derivatives. Cell Rep. 2017 Aug 29;20(9):2116-2130
• All: 1 reference(s)