Spic^tm1.1Ksho
Targeted Allele Detail

Summary

• Symbol: Spic^tm1.1Ksho
• Name: Spi-C transcription factor (Spi-1/PU.1 related); targeted mutation 1.1, Tsuneyasu Kaisho
• MGI ID: MGI:7378274
• Gene: Spic Location: Chr10:88511131-88518885 bp, - strand Genetic Position: Chr10, 44.14 cM, cytoband C
• Alliance: Spic^tm1.1Ksho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:265082
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• The targeting construct floxed exon 6. Recombination removed the selection cassette. (J:265082)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Spic Mutation: 24 strains or lines available

References

• Original: J:265082 Kayama H, et al., Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):8418-8423
• All: 1 reference(s)