Rora^tm1.1Shkm
Targeted Allele Detail

Summary

• Symbol: Rora^tm1.1Shkm
• Name: RAR-related orphan receptor alpha; targeted mutation 1.1, Shigeo Koyasu
• MGI ID: MGI:7378273
• Gene: Rora Location: Chr9:68561068-69295528 bp, + strand Genetic Position: Chr9, 37.45 cM
• Alliance: Rora^tm1.1Shkm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:288763
• Parent Cell Line: B6JN/1 (ES Cell)
• Strain of Origin: (C57BL/6N x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• The targeting construct floxed exon 3. Flp-mediated recombination removed the selection cassette. (J:288763)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rora Mutation: 43 strains or lines available

References

• Original: J:288763 Satoh-Takayama N, et al., Bacteria-Induced Group 2 Innate Lymphoid Cells in the Stomach Provide Immune Protection through Induction of IgA. Immunity. 2020 Apr 14;52(4):635-649.e4
• All: 2 reference(s)