Gpihbp1^em1Sgy
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gpihbp1^em1Sgy
• Name: GPI-anchored HDL-binding protein 1; endonuclease-mediated mutation 1, Stephen G Young
• MGI ID: MGI:7367586
• Synonyms: Gpihbp1^D
• Gene: Gpihbp1 Location: Chr15:75468479-75470062 bp, + strand Genetic Position: Chr15, 34.59 cM, cytoband E1
• Alliance: Gpihbp1^em1Sgy page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination removed a 66 bp region including amino acids 27 to 48 encoding for the sulfated tyrosine and long stretch of acidic residues in exon 2. Western blot analysis confirmed the absence of protein expression in heart extracts from homozygous mice. (J:330319)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpihbp1 Mutation: 18 strains or lines available

References

• Original: J:330319 Song W, et al., Electrostatic sheathing of lipoprotein lipase is essential for its movement across capillary endothelial cells. J Clin Invest. 2022 Mar 1;132(5):e157500
• All: 1 reference(s)