Gpihbp1^em2Sgy
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gpihbp1^em2Sgy
• Name: GPI-anchored HDL-binding protein 1; endonuclease-mediated mutation 2, Stephen G Young
• MGI ID: MGI:7367585
• Synonyms: Gpihbp1^S
• Gene: Gpihbp1 Location: Chr15:75468479-75470062 bp, + strand Genetic Position: Chr15, 34.59 cM, cytoband E1
• Alliance: Gpihbp1^em2Sgy page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/cas9 mediated recombination replaced the sulfated tyrosine and long stretch of acidic residues (DDDDDEEEEEE) with an S-protein tag (KETAAAKFERQHMDS). Western blot analysis confirmed the expression of mutant protein in homozygous mice. (J:330319)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpihbp1 Mutation: 18 strains or lines available

References

• Original: J:330319 Song W, et al., Electrostatic sheathing of lipoprotein lipase is essential for its movement across capillary endothelial cells. J Clin Invest. 2022 Mar 1;132(5):e157500
• All: 1 reference(s)