Kctd13^em1Djla
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kctd13^em1Djla
• Name: potassium channel tetramerisation domain containing 13; endonuclease-mediated mutation 1, Dolores J Lamb
• MGI ID: MGI:7367571
• Gene: Kctd13 Location: Chr7:126528051-126544781 bp, + strand Genetic Position: Chr7, 69.25 cM
• Alliance: Kctd13^em1Djla page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology deleted exon 2 producing a frameshift and a premature stop codon in exon 3, which is predicted to cause nonsense-mediated decay of the mutant transcript. Western blot analysis confirmed absence of protein in testicular extracts and immunohistochemistry confirmed absence in testes in homozygotes. (J:330265)

Expression

In Mice Carrying this Mutation:	34 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kctd13 Mutation: 13 strains or lines available

References

• Original: J:330265 Seth A, et al., Gene dosage changes in KCTD13 result in penile and testicular anomalies via diminished androgen receptor function. FASEB J. 2022 Nov;36(11):e22567
• All: 1 reference(s)