Il2^tm1.1Ciphe
Targeted Allele Detail

Summary

• Symbol: Il2^tm1.1Ciphe
• Name: interleukin 2; targeted mutation 1.1, Centre d'ImmunoPhenomique
• MGI ID: MGI:7365286
• Synonyms: Il2^flox, Il2^Tm1Ciphe
• Gene: Il2 Location: Chr3:37174862-37180103 bp, - strand Genetic Position: Chr3, 18.3 cM, cytoband B-C
• Alliance: Il2^tm1.1Ciphe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:330105
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted 173 bp upstream of exon 3 and an FRT-flanked neomycin resistance gene and second loxP site were inserted 150 bp downstream of exon 3. The neomycin resistance gene was removed via flp-mediated recombination leaving exon 3 floxed. (J:330105)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il2 Mutation: 39 strains or lines available

References

• Original: J:330105 Apert C, et al., IL-2 and IL-15 drive intrathymic development of distinct periphery-seeding CD4(+)Foxp3(+) regulatory T lymphocytes. Front Immunol. 2022;13:965303
• All: 1 reference(s)