Gstm1^em1Jgao
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gstm1^em1Jgao
• Name: glutathione S-transferase, mu 1; endonuclease-mediated mutation 1, Jiangang Gao
• MGI ID: MGI:7365213
• Gene: Gstm1 Location: Chr3:107919571-107925289 bp, - strand Genetic Position: Chr3, 46.83 cM, cytoband F3
• Alliance: Gstm1^em1Jgao page

Mutation origin

• Strain of Origin: CBA/CaJ

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 5 bp deletion (atccg) in exon 2. qPCR indicates that mRNA levels are dramatically decreased in the cochlea and Western blot analysis confirmed absence of protein. (J:330099)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gstm1 Mutation: 26 strains or lines available

References

• Original: J:330099 Li P, et al., Gstm1/Gstt1 is essential for reducing cisplatin ototoxicity in CBA/CaJ mice. FASEB J. 2022 Jun;36(6):e22373
• All: 1 reference(s)