Rbm46^em1Rpc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rbm46^em1Rpc
• Name: RNA binding motif protein 46; endonuclease-mediated mutation 1, Russ P Carstens
• MGI ID: MGI:7356597
• Gene: Rbm46 Location: Chr3:82744535-82783790 bp, - strand Genetic Position: Chr3, 36.75 cM
• Alliance: Rbm46^em1Rpc page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a frameshifting deletion between exons 2-3. This frameshift in the region encoding the first RNA Recognition Motif (RRM) led to a premature termination codon that disrupted all three consensus RRMs. (J:330079)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rbm46 Mutation: 25 strains or lines available

References

• Original: J:330079 Peart NJ, et al., The germ cell-specific RNA binding protein RBM46 is essential for spermatogonial differentiation in mice. PLoS Genet. 2022 Sep;18(9):e1010416
• All: 1 reference(s)