Far2^em1Akih
Endonuclease-mediated Allele Detail

Summary

• Symbol: Far2^em1Akih
• Name: fatty acyl CoA reductase 2; endonuclease-mediated mutation 1, Akio Kihara
• MGI ID: MGI:7354967
• Gene: Far2 Location: Chr6:147948914-148084256 bp, + strand Genetic Position: Chr6, 78.49 cM
• Alliance: Far2^em1Akih page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology targeting the 20 bases adjacent to the protospacer-adjacent motif generated a 7 bp deletion in exon 2 near the start codon. (J:329410)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Far2 Mutation: 33 strains or lines available

References

• Original: J:329410 Otsuka K, et al., Formation of fatty alcohols-components of meibum lipids-by the fatty acyl-CoA reductase FAR2 is essential for dry eye prevention. FASEB J. 2022 Apr;36(4):e22216
• All: 1 reference(s)