Chmp4b^tm1.1Alsh
Targeted Allele Detail

Summary

• Symbol: Chmp4b^tm1.1Alsh
• Name: charged multivesicular body protein 4B; targeted mutation 1.1, Alan Shiels
• MGI ID: MGI:7346081
• Synonyms: Chmp4b^D129V
• Gene: Chmp4b Location: Chr2:154498949-154536703 bp, + strand Genetic Position: Chr2, 76.79 cM, cytoband H2
• Alliance: Chmp4b^tm1.1Alsh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:282278
• Parent Cell Line: SCC10 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Single point mutation
• Mutation details: The targeting vector replaced exon 3 with a modified one with the mutation (c.386A to T) responsible to the amino acid substitution of aspartic acid with valine at position 129 (D129V). Cre-mediated recombination removed the selection cassette inserted downstream of exon 4. (J:282278)

Expression

In Mice Carrying this Mutation:

12 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chmp4b Mutation: 39 strains or lines available

References

• Original: J:282278 Zhou Y, et al., A charged multivesicular body protein (CHMP4B) is required for lens growth and differentiation. Differentiation. 2019 Sep - Oct;109:16-27
• All: 1 reference(s)