Ttc39c^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ttc39c^em1(IMPC)J
• Name: tetratricopeptide repeat domain 39C; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:7343914
• Gene: Ttc39c Location: Chr18:12732953-12871920 bp, + strand Genetic Position: Chr18, 6.71 cM, cytoband A2
• Alliance: Ttc39c^em1(IMPC)J page
• IMPC: Ttc39c gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences GCTAGATCATGGCCAAAGGA and GCGTATATATGATTTTTAGA, which resulted in a 510 bp deletion beginning at Chromosome 18 position 12,817,618 bp and ending after 12,818,127 bp (GRCm38/mm10). This mutation deletes ENSMUSE00001244258 (exon 2) and 461 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 53 and early truncation 2 amino acids later. (J:188991)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ttc39c Mutation: 38 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 1 reference(s)