Cyld^tm1.2Gmos
Targeted Allele Detail

Summary

• Symbol: Cyld^tm1.2Gmos
• Name: CYLD lysine 63 deubiquitinase; targeted mutation 1, George Mosialos
• MGI ID: MGI:7343872
• Gene: Cyld Location: Chr8:89423675-89478573 bp, + strand Genetic Position: Chr8, 43.51 cM
• Alliance: Cyld^tm1.2Gmos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162840
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of exon 9 and an additional loxP site was inserted downstream of exon 9. Cre-mediated recombination removed the selection cassette and left exon 9 floxed. (J:162840)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cyld Mutation: 45 strains or lines available

References

• Original: J:162840 Trompouki E, et al., Truncation of the catalytic domain of the cylindromatosis tumor suppressor impairs lung maturation. Neoplasia. 2009 May;11(5):469-76
• All: 1 reference(s)