Nf1^em1Emcs
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nf1^em1Emcs
• Name: neurofibromin 1; endonuclease-mediated mutation 1, Efthimios MC Skoulakis
• MGI ID: MGI:7343853
• Gene: Nf1 Location: Chr11:79230519-79472438 bp, + strand Genetic Position: Chr11, 46.74 cM, cytoband B4-5
• Alliance: Nf1^em1Emcs page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-targeting of exon 38 introduced the mutation responsible for the amino acid substitution of arginine for cysteine at position 1809 (R1809C). (J:329328)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nf1 Mutation: 158 strains or lines available

References

• Original: J:329328 Skoulakis EMC, An Interspecies Approach to Model Differential Cognitive Effects of Specific Neurofibromin I Mutations. 2022
• All: 1 reference(s)