Tg(Rr279*-EGFP)deltanPE1coreMrub
Transgene Detail

Summary

• Symbol: Tg(Rr279*-EGFP)deltanPE1coreMrub
• Name: transgene insertion deltanPE1core, Marcelo Rubinstein
• MGI ID: MGI:7343824
• Synonyms: deltanPE1core, nPE1deltacorePomc-EGFP
• Transgene: Tg(Rr279*-EGFP)deltanPE1coreMrub Location: unknown
• Alliance: Tg(Rr279*-EGFP)deltanPE1coreMrub page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: The transgene contains the following elements: a neuron-specific enhancers-containing region 6.5-13 kb upstream of the Pomc gene transcription start site with enhancer Rr280 deleted but a modified Rr279 (where the 144 bp core sequence was deleted from the 630 bp region) still present, and the Pomc gene, including 0.8 kb of upstream and 8 kb of downstream sequence, with the EGFP reporter gene and SV40 poly(A) signal sequences inserted upstream of the translation start site. The transgene is not expressed in the hypothalamic arcuate neurons but is expressed in the pituitary gland during embryonic development. (J:176451)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:176451 Franchini LF, et al., Convergent evolution of two mammalian neuronal enhancers by sequential exaptation of unrelated retroposons. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15270-5
• All: 1 reference(s)