Tg(Pomc)#5deltaMrub
Transgene Detail

Summary

• Symbol: Tg(Pomc)#5deltaMrub
• Name: transgene insertion 5delta, Marcelo Rubinstein
• MGI ID: MGI:7343816
• Synonyms: P27*5'delta
• Transgene: Tg(Pomc)#5deltaMrub Location: unknown
• Alliance: Tg(Pomc)#5deltaMrub page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Pomc)#5deltaMrub expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Pomc (MGI:97742)	tagged with a random 34 bp sequence in the coding sequence of exon 3

• Mutation details: The transgene contains a tagged 16 kb of the mouse gene encompassing three exons, two introns, and 2 kb of the 5' and 8 kb of 3' flanking sequences. The modification involves the insertion of a random 34 bp sequence in the coding sequence of exon 3, allowing for distinguishing transgene transcripts from endogenous transcripts. The transgene is expressed in the pituitary gland but not in brain neurons. (J:49226)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:49226 Young JI, et al., Authentic cell-specific and developmentally regulated expression of pro-opiomelanocortin genomic fragments in hypothalamic and hindbrain neurons of transgenic mice. J Neurosci. 1998 Sep 1;18(17):6631-40
• All: 1 reference(s)