Tg(Pomc)#3deltaMrub
Transgene Detail

Summary

• Symbol: Tg(Pomc)#3deltaMrub
• Name: transgene insertion 3delta, Marcelo Rubinstein
• MGI ID: MGI:7343815
• Synonyms: P27*3'delta
• Transgene: Tg(Pomc)#3deltaMrub Location: unknown
• Alliance: Tg(Pomc)#3deltaMrub page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Pomc)#3deltaMrub expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Pomc (MGI:97742)	tagged with a random 34 bp sequence in the coding sequence of exon 3

• Mutation details: The transgene contains a tagged 21 kb of the mouse gene encompassing three exons, two introns, and 13 kb of the 5' and 2 kb of 3' flanking sequences. The modification involves the insertion of a random 34 bp sequence in the coding sequence of exon 3, allowing for distinguishing transgene transcripts from endogenous transcripts. The transgene is expressed in brain neurons and in the pituitary gland. (J:49226)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:49226 Young JI, et al., Authentic cell-specific and developmentally regulated expression of pro-opiomelanocortin genomic fragments in hypothalamic and hindbrain neurons of transgenic mice. J Neurosci. 1998 Sep 1;18(17):6631-40
• All: 1 reference(s)