Tg(Pomc)#Mrub
Transgene Detail

Summary

• Symbol: Tg(Pomc)#Mrub
• Name: transgene insertion, Marcelo Rubinstein
• MGI ID: MGI:7343814
• Synonyms: POMC27*
• Transgene: Tg(Pomc)#Mrub Location: unknown
• Alliance: Tg(Pomc)#Mrub page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Pomc)#Mrub expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Pomc (MGI:97742)	tagged with a random 34 bp sequence in the coding sequence of exon 3

• Mutation details: The transgene contains a tagged 27 kb of the mouse gene encompassing three exons, two introns, and 13 kb of the 5' and 8 kb of 3' flanking sequences. The modification involves the insertion of a random 34 bp sequence in the coding sequence of exon 3, allowing for distinguishing transgene transcripts from endogenous transcripts. During embryonic development the transgene is expressed in the arcuate nucleus of the hypothalamus and the developing diencephalon, spinal cord, and nucleus of the tractus solitarius. (J:49226)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:49226 Young JI, et al., Authentic cell-specific and developmentally regulated expression of pro-opiomelanocortin genomic fragments in hypothalamic and hindbrain neurons of transgenic mice. J Neurosci. 1998 Sep 1;18(17):6631-40
• All: 1 reference(s)