Grm7^em1Nisvu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Grm7^em1Nisvu
• Name: glutamate receptor, metabotropic 7; endonuclease-mediated mutation 1, Colleen Niswender
• MGI ID: MGI:7343632
• Synonyms: Grm7^I154T
• Gene: Grm7 Location: Chr6:110622542-111544191 bp, + strand Genetic Position: Chr6, 51.19 cM
• Alliance: Grm7^em1Nisvu page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced the mutation responsible for the amino acid substitution isoleucine with threonine at position 154 (I154T). (J:329223)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grm7 Mutation: 126 strains or lines available

References

• Original: J:329223 Fisher NM, et al., A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes. JCI Insight. 2021 Feb 22;6(4)
• All: 1 reference(s)