Tg(Rr596*-EGFP)8Mrub
Transgene Detail

Summary

• Symbol: Tg(Rr596*-EGFP)8Mrub
• Name: transgene insertion 8, Marcelo Rubinstein
• MGI ID: MGI:7341854
• Synonyms: Tg(Rr279-EGFP)8Mrub
• Transgene: Tg(Rr596*-EGFP)8Mrub Location: unknown
• Alliance: Tg(Rr596*-EGFP)8Mrub page

Transgene origin

• Strain of Origin: either: (C57BL/6 x CBA)F2 or (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: The transgene contains the following: the Pomc gene, including sequence 8 kb downstream of the transcription start site and 13 kb upstream, containing pituitary-specific enhancer Rr281 but with neuron-specific enhancer Rr280 (nPE2) deleted (172 bp) and Rr279 (nPE1) still present, and the promoter, with the EGFP reporter gene and SV40 poly(A) signal sequences inserted upstream of the translation start site. The transgene is expressed in pituitary melanotrophs and corticotrophs and in hypothalamic arcuate neurons during embryonic development. (J:97636)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:97636 de Souza FS, et al., Identification of neuronal enhancers of the proopiomelanocortin gene by transgenic mouse analysis and phylogenetic footprinting. Mol Cell Biol. 2005 Apr;25(8):3076-86
• All: 1 reference(s)