Scn11a^em1Smya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Scn11a^em1Smya
• Name: sodium channel, voltage-gated, type XI, alpha; endonuclease-mediated mutation 1, Shi-Ming Yang
• MGI ID: MGI:7341829
• Synonyms: Nav1.9^-
• Gene: Scn11a Location: Chr9:119582829-119654522 bp, - strand Genetic Position: Chr9, 71.33 cM, cytoband F3-F4
• Alliance: Scn11a^em1Smya page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology deleted 347 bp, staring in exon 3 and ending in exon 5, leading to a reading frame shift mutation followed by a premature translational-termination codon. (J:329152)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn11a Mutation: 89 strains or lines available

References

• Original: J:329152 Zu M, et al., SCN11A gene deletion causes sensorineural hearing loss by impairing the ribbon synapses and auditory nerves. BMC Neurosci. 2021 Mar 22;22(1):18
• All: 1 reference(s)