Meig1^em1Zzha
Endonuclease-mediated Allele Detail

Summary

• Symbol: Meig1^em1Zzha
• Name: meiosis expressed gene 1; endonuclease-mediated mutation 1, Zhibing Zhang
• MGI ID: MGI:7341509
• Synonyms: MEIG1^Y68A
• Gene: Meig1 Location: Chr2:3410080-3423685 bp, - strand Genetic Position: Chr2, 1.92 cM
• Alliance: Meig1^em1Zzha page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology generated a TAC to GCC change resulting in a tyrosine to alanine substitution at amino acid 68 (p.Y68A). Western blot analysis confirmed expression of protein in the testis. (J:328980)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Meig1 Mutation: 14 strains or lines available

References

• Original: J:328980 Li W, et al., A single amino acid mutation in the mouse MEIG1 protein disrupts a cargo transport system necessary for sperm formation. J Biol Chem. 2021 Oct 19;297(5):101312
• All: 1 reference(s)