Sting1^em1Tcb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sting1^em1Tcb
• Name: stimulator of interferon response cGAMP interactor 1; endonuclease-mediated mutation 1, Thomas Brodnicki
• MGI ID: MGI:7341356
• Gene: Sting1 Location: Chr18:35866732-35873607 bp, - strand Genetic Position: Chr18, 19.23 cM, cytoband B3
• Alliance: Sting1^em1Tcb page

Mutation origin

• Strain of Origin: NOD/ShiLtJ

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology deleted 962 bp encompassing exons 3, 4, and 5. (J:328887)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sting1 Mutation: 49 strains or lines available

References

• Original: J:328887 Akazawa S, et al., Deficiency of the innate immune adaptor STING promotes autoreactive T cell expansion in NOD mice. Diabetologia. 2021 Apr;64(4):878-889
• All: 1 reference(s)