Rbck1^tm1Jis
Targeted Allele Detail

Summary

• Symbol: Rbck1^tm1Jis
• Name: RanBP-type and C3HC4-type zinc finger containing 1; targeted mutation 1, Jacob I Sznajder
• MGI ID: MGI:7339255
• Synonyms: HOIL-1L^fl
• Gene: Rbck1 Location: Chr2:152158254-152174573 bp, - strand Genetic Position: Chr2, 74.83 cM
• Alliance: Rbck1^tm1Jis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:254318
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 8 and exons 8-13, a second loxP site, and a neomycin resistance gene were inserted downstream of exon 8. (J:254318)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rbck1 Mutation: 41 strains or lines available

References

• Original: J:254318 Magnani ND, et al., HIF and HOIL-1L-mediated PKCzeta degradation stabilizes plasma membrane Na,K-ATPase to protect against hypoxia-induced lung injury. Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):E10178-E10186
• All: 2 reference(s)