Ch25h^tm1.1Syfu
Targeted Allele Detail

Summary

• Symbol: Ch25h^tm1.1Syfu
• Name: cholesterol 25-hydroxylase; targeted mutation 1.1, Serge Fuchs
• MGI ID: MGI:7336292
• Gene: Ch25h Location: Chr19:34451183-34452548 bp, - strand Genetic Position: Chr19, 29.69 cM
• Alliance: Ch25h^tm1.1Syfu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:328474
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector is composed of a neomycin (neo) cassette flanked by self-deletion anchor sites (SDA) and diphtheria toxin A (DTA), which is used for negative selection. The loxP sites were inserted ~1.8 kb upstream of exon 1 and ~0.5 kb downstream of exon 1. (J:328474)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ch25h Mutation: 23 strains or lines available

References

• Original: J:328474 Lu Z, et al., Regulation of intercellular biomolecule transfer-driven tumor angiogenesis and responses to anticancer therapies. J Clin Invest. 2021 May 17;131(10)
• All: 3 reference(s)