Cav1^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cav1^em1Cya
• Name: caveolin 1, caveolae protein; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:7336291
• Synonyms: Cav-1^-
• Gene: Cav1 Location: Chr6:17306387-17341323 bp, + strand Genetic Position: Chr6, 7.73 cM, cytoband A2
• Alliance: Cav1^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology targeted exon 2 for deletion. (J:328486)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cav1 Mutation: 33 strains or lines available

References

• Original: J:328486 Liu W, et al., Low shear stress inhibits endothelial mitophagy via caveolin-1/miR-7-5p/SQSTM1 signaling pathway. Atherosclerosis. 2022 Sep;356:9-17
• All: 1 reference(s)