Gt(ROSA)26Sor^{em1(CAG-Osbp2,-EGFP)Dya}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{em1(CAG-Osbp2,-EGFP)Dya}
• Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Daoguang Yan
• MGI ID: MGI:7336175
• Synonyms: ORP4L KI
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{em1(CAG-Osbp2,-EGFP)Dya} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{em1(CAG-Osbp2,-EGFP)Dya} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  HTLV-1	tax (1491938)

• Gt(ROSA)26Sor^{em1(CAG-Osbp2,-EGFP)Dya} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Lck

• Mutation details: A CAG promotor, loxP-flanked stop cassette, Osbp2 cDNA with a Flag tag, IRES, EGFP, and WPRE were inserted into the locus. (J:328286)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1089 strains or lines available

References

• Original: J:328286 Zhong W, et al., An acquired phosphatidylinositol 4-phosphate transport initiates T-cell deterioration and leukemogenesis. Nat Commun. 2022 Jul 29;13(1):4390
• All: 1 reference(s)