Kdm6b^em1Kaig
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kdm6b^em1Kaig
• Name: KDM1 lysine (K)-specific demethylase 6B; endonuclease-mediated mutation 1, Kai Ge
• MGI ID: MGI:7336154
• Synonyms: JMJD3^ssDD
• Gene: Kdm6b Location: Chr11:69289334-69304501 bp, - strand Genetic Position: Chr11, 42.6 cM
• Alliance: Kdm6b^em1Kaig page

Mutation origin

• Strain of Origin: (C57BL/6J x DBA/2J)F1/J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology introduced histidine to alanine and glutamate to alanine point mutations at positions 1388 (H1288A) and 1290 (E1390A) in the Jmjc domain. These point mutations produce a demethylase dead protein. (J:101977, J:328273)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kdm6b Mutation: 66 strains or lines available

References

• Original: J:328273 Nakka K, et al., JMJD3 activated hyaluronan synthesis drives muscle regeneration in an inflammatory environment. Science. 2022 Aug 5;377(6606):666-669
• All: 2 reference(s)